Decreased NK cell activity after partial vulvectomy in pregnant patient with vulvar intraepithelial neoplasia 3 (VIN3)

Malgorzata Jerzak 1, Andrzej Nowakowski 1, Monika Ohams 2, Andrzej Górski 2, Włodzimierz Baranowsk 1
1 - Department of Gynecology and Gynecological Oncology, Military Institute of Medicine, Warsaw, Poland
2 - Department of Clinical Immunology, Transplantation Institute, University Medical School, Warsaw, Poland
Ann Agric Environ Med

ICID: 1235167
Article type: Original article
Introduction and objective
. The study presents the problem of immune disturbances in pregnant women with vulvar carcinoma in situ (VIN3).
Material and methods. NK cell and T reg activity in the study patient were analysed using flow cytometry.
Results. Decreased NK cell activity and but increased T reg activity were observed after vulvectomy, with subsequent successful pregnancy outcome.
Conclusions. Although vulvar cancer may influence immune cell activity, this issue merits further study
DOI: 10.5604/12321966.1235167

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