Prostate cancer in patients from rural and suburban areas – PSA value, Gleason score and presence of metastases in bone scan

Wojciech Szot 1, Magdalena Kostkiewicz 2, Joanna Zając 3, Alfred Owoc 4, Iwona Bojar 5
1 - Hygiene and Diet Department, Jagiellonian University Medical College, Cracow, Poland; Nuclear Medicine Department, John Paul II Hospital, Cracow, Poland
2 - Nuclear Medicine Department, John Paul II Hospital, Cracow, Poland; Cardiovascular Diseases Department, Jagiellonian University Medical College, Cracow, Poland
3 - Hygiene and Diet Department, Jagiellonian University Medical College, Cracow, Poland
4 - Higher School of Public Health, Zielona Góra, Poland
5 - Department for Health Problems of Ageing, Institute of Rural Health, Lublin, Poland
Ann Agric Environ Med
2014; 21 (4):
ICID: 1129953
 
 
Introduction. Prostate cancer is the second most common neoplasm among men both worldwide and in Poland.
In prostate cancer, bone metastasis is related to a poorer prognosis. A diagnosis of metastatic bone disease is important in prostate cancer patients prior to therapy. Prostate specific antigen (PSA) serum value is used both as a screening tool and for staging of prostate cancer.
aim. To evaluate whether there is a link between symptoms presented by patients, pain in particular, and the presence, number and location of bone metastases as assessed by bone scan scintigraphy in concordance with PSA values and Gleason scores.
material. A group of 186 patients (aged: 68.38±6.16) diagnosed with prostate cancer, from rural and suburban areas of Małopolska province, that was directed for bone scan scintigraphy to the Nuclear Medicine Dept, John Paul II Hospital in Kraków.
methods. Analysis of all laboratory findings (including PSA value) and a biopsy were performed. Then, bone scan scintigraphy was done with the use of methylene disphosphonate (MDP) labeled with Tc-99m.
results. In patients with a Gleason value ≤7 and a PSA value ≤20 ng/ml, the cutoff value for a negative bone scan with a confidence interval of 0.95 was established at a PSA value below 10 ng/ml (p<0.01). Correlations were established between PSA value and presence of metastases in bone scan (r=0.45, p=0.05), the number of metastases (r=0.66, p<0.01), and their presence in particular body regions.
conclusions. The correlation between PSA value and both presence and number of metastases confirms the usefulness of bone scan scintigraphy in prostate cancer staging. The cutoff value for negative bone scan with a 95% confidence interval was established at PSA = 10 ng/ml.

DOI: 10.5604/12321966.1129953
PMID 25528940 - click here to show this article in PubMed
  FULL TEXT STATS

Recommend this article to:

Name:
E-mail:
From:
Language:


Related articles in IndexCopernicus™
     PSA value [0 related records]
     metastases [64 related records]
     bone scan [10 related records]
     prostate cancer [160 related records]



 

Related articles

O Alonso, G Santos,
False-Positive Results of 68ga-Dotatate and 11c-Ch...
Objective: For an oncological tracer is relevant to know the uptake in inflamed/infected lesions. Thus, in the framework of a prospective trial aiming to compare the clinical value of 68Ga-DOTATATE and 11C-Choline PET/CT in patients with hormone-resi...
ABSTRACT
Z Zdrojewicz, E Pachura,
działanie lecznicze owoców pomidora zwyczajnego&...
 ...
ABSTRACT
T Yıkılmaz, E Öztürk,
Yüksek Riskli Prostat Kanserinde Radikal Prostate...
Amaç: Yüksek riskli prostat kanserinin tedavisinde cerra­hi ve radyoterapi seçenekleri bulunmaktadır. Günümüzde cerrahi tecrübenin artması nedeniyle yüksek riskli gruba da cerrahi uygulayan merkezler bulunmaktadır. Kliniği­mizde yükse...
ABSTRACT